People

Christian Bleiholder

Tel: 805-893-2673

E-mail: cbleiholder@chem.ucsb.edu

My research in the Bowers group focuses on elucidating how peptides aggregate to form amyloid fibrils. Amyloid fibrils are indicative of a number of diseases, including Alzheimer's and Parkinson's Disease as well as Diabetes Type 2. My research focuses on the structure and reactions of the soluble early aggregation states. The techniques I apply to this end include mass spectrometry, ion mobility spectrometry, as well as molecular dynamics simulations.

Previous work involved quantum mechanical modeling of transition metal complexes, chalcogen-chalcogen interactions, as well as the gas-phase chemistry of protonated peptides.

Publications

• Fragmentation pathways of doubly protonated tryptic peptides
  C. Bleiholder, S. Suhai, Á. Somogyi, B. Paizs
  J. Am. Soc. Mass Spectrom. (submitted for publication)
• Competing fragmentation pathways for protonated H-Val-Asn-OH, H-Val-Gln-OH, and H-Val-Lys-OH
  C. Bleiholder, S. Suhai, B. Paizs
  Theo. Chem. Acc. (submitted for publication)
• Intramolecular nonbonded interactions between divalent selenium centers with donor and acceptor substituents
  A. Lari, C. Bleiholder, F. Rominger, R. Gleiter
  Eur. J. Org. Chem. 2009, 17, 2765-2774
• α-Metallocenylmethylium ions and their isoelectronic congeners - a comparison based on DFT calculations
  C. Bleiholder, F. Rominger, R. Gleiter
  Organometallics 2009, 28, 1014-1017
• Sequence scrambling fragmentation pathways of protonated peptides
  C. Bleiholder, S. Osburn, T. Williams, S. Suhai, M. Van Stipdonk, A. Harrison, B. Paizs
  J. Am. Chem. Soc. 2008, 130, 17774–17789
• α-Metallocenylmethylium ions of d6 to d9 metals. Structural considerations
  R. Gleiter, C. Bleiholder, F. Rominger
  Organometallics 2007, 26, 4850-4859
• Unimolecular chemistry of metal ion-coordinated α-dipeptide radicals
  F. Pingitore, C. Bleiholder, B. Paizs, C. Wesdemiotis
  Int. J. Mass Spectrom. 2007, 265, 251-260
• Theoretical investigations on heteronuclear chalcogen-chalcogen interactions: On the nature of weak bonds between chalcogen centers
  C. Bleiholder, R. Gleiter, D. B. Werz, H. Köppel
  Inorg. Chem. 2007, 46, 2249-2260
• Transannular interactions in mixed superphanes with one thiophene and one CpCo-stabilized cyclobutadiene ring: Syntheses, structures, and electrochemistry
  S. Gath, R. Gleiter, F. Rominger, C. Bleiholder
  Organometallics 2007, 26, 644–650
• Scrambling of sequence information in collision-induced dissociation of peptides
  A. G. Harrison, A. B. Young, C. Bleiholder, S. Suhai, B. Paizs
  J. Am. Chem. Soc. 2006, 128, 10364-10365
• Strong distortions in hexacarbonyldicobalt complexes by push-pull effects
  D. B. Werz, C. Bleiholder, R. Gleiter, F. Rominger
  J. Organomet. Chem. 2006, 691, 3943-3947
• Dissociation pathways of singly charged dilithiated peptides
  C. Wesdemiotis, P. Wang, A. Leigh, M. J. Polce, C. Bleiholder, B. Paizs
  In Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, USA, May 28 – June 1, 2006, p. 282
• Improving the reliability of protein identification using peptide mass fingerprinting by probability based scoring of amino acid modifications
  C. Bleiholder, S. Fiedler, B. Paizs, M. Schnölzer
  In Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, USA, May 28 – June 1, 2006, p. 581
• Fragmentation mechanisms of protonated peptides
  C. Bleiholder, S. Suhai, B. Paizs
  In Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, USA, May 28 – June 1, 2006, p. 1875
• Effective temperatures and the mobile proton in activated ions, evaluated by thermal extrapolation and by ab initio calculations
  M. Mautner, A. Somogyi, C. Bleiholder, B. Paizs
  In Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics, Seattle, WA, USA, May 28 – June 1, 2006, p. 2319
• Revising the proton affinity scale of the naturally occuring α-amino acids
  C. Bleiholder, S. Suhai, B. Paizs
  J. Am. Soc. Mass Spectrom. 2006, 17, 1275-1281
• Structural characterization of peptides via tandem mass spectrometry of their dilithiated monocations
  P. Wang, M. J. Polce, C. Bleiholder, B. Paizs, C. Wesdemiotis
  Int. J. Mass Spectrom. 2006, 249, 45-59
• Theoretical investigations on chalcogen-chalcogen-interactions: What makes these nonbonded interactions bonding?
  C. Bleiholder, D. B. Werz, H. Köppel, R. Gleiter
  J. Am. Chem. Soc. 2006, 128, 2666-2674
• Coordination chemistry of a new rigid, hexadentate bispidine-based bis(amine)tetrakis(pyridine) ligand
  C. Bleiholder, H. Borzel, P. Comba, R. Ferrari, M. Heydt, M. Kerscher, S. Kuwata, G. Laurenczy, G. A. Lawrance, A. Lienke, B. Martin, M. Merz, B. Nuber, H. Pritzkow
  Inorg. Chem. 2005, 44, 8145-8155